TY  - BOOK
AU  - Lock,Margaret
TI  - The Alzheimer Conundrum: Entanglements of Dementia and Aging 
SN  - 9780691149783
AV  - RC521 
U1  - 362.19683 23
PY  - 2013///]
CY  - Princeton, NJ : 
PB  - Princeton University Press, 
KW  - Alzheimer's disease
KW  - Age factors
KW  - Brain
KW  - Aging
KW  - Molecular aspects
KW  - Dementia
KW  - Electronic books
KW  - Older people
KW  - Mental health
KW  - SOCIAL SCIENCE / Anthropology / General
KW  - bisacsh
KW  - APOE
KW  - Alois Alzheimer
KW  - Alzheimer disease
KW  - Alzheimer enterprise
KW  - Alzheimer genetics
KW  - Alzheimer prevention
KW  - Alzheimer world
KW  - DNA samples
KW  - DNA
KW  - GWAS
KW  - Huntington disease
KW  - aging population
KW  - aging populations
KW  - aging societies
KW  - amyloid cascade hypothesis
KW  - amyloid cascade process
KW  - behavioral changes
KW  - biomarkers
KW  - biosociality
KW  - breast cancer
KW  - clinical diagnosis
KW  - clinical settings
KW  - control samples
KW  - dementia
KW  - diagnosis
KW  - divination
KW  - early-onset
KW  - environmental variables
KW  - epidemiological research
KW  - epidemiology
KW  - epigenetics
KW  - ethnographic research
KW  - expert knowledge
KW  - family practice settings
KW  - gene function
KW  - genes
KW  - genetic testing
KW  - geneticization
KW  - genome-wide association studies
KW  - genomics
KW  - global economy
KW  - late-onset
KW  - localization theory
KW  - medical publications
KW  - memory clinics
KW  - memory loss
KW  - micro-medical management
KW  - mild cognitive impairment
KW  - molecular approach
KW  - molecular biologists
KW  - molecularization
KW  - neuritic amyloid plaques
KW  - neurofibrillary tangles
KW  - neuroimaging
KW  - prevention
KW  - prodromal
KW  - public health
KW  - research
KW  - throughput technology
N1  - Frontmatter --; Contents --; Acknowledgments --; Orientations --; Chapter 1. Making And Remaking Alzheimer Disease --; Chapter 2. Striving to Standardize Alzheimer Disease --; Chapter 3. Paths to Alzheimer Prevention --; Chapter 4. Embodied Risk Made Visible --; Chapter 5. Alzheimer Genes: Biomarkers of Prediction and Prevention --; Chapter 6. Genome- Wide Association Studies: Back to the Future --; Chapter 7. Living with Embodied Omens --; Chapter 8. Chance Untamed and the Return of Fate --; Chapter 9. Transcending Entrenched Tensions --; Afterword. Portraits from the Mind --; Notes --; Index; restricted access; Issued also in print
N2  - Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer's disease through early detection of pre-symptomatic biological changes in healthy individuals.Based on a meticulous account of the history of Alzheimer's disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure
UR  - https://doi.org/10.1515/9781400848461?locatt=mode:legacy
UR  - https://www.degruyter.com/isbn/9781400848461
UR  - https://www.degruyter.com/cover/covers/9781400848461.jpg
ER  -